foxp3 and tgf-β gene polymorphisms in allergic rhinitis
Authors
abstract
background: regulatory cd4+t (treg) cells are effective in maintaining immune tolerance. objective: to investigate single nucleotide polymorphisms (snps) of transforming growth factor β-1 (tgf-β1) and forkhead box protein 3 (foxp3) genes in iranian patients with allergic rhinitis (ar). methods: variations at codons 10 and 25 of tgf-β1 and foxp3 at positions -3279 a>c and -924 a>g were evaluated in ar patients and compared with controls. in a case-control study, 155 ar patients and 163 allergy- free controls were genotyped using polymerase chain reaction sequence-specific primer (pcr-ssp) technique. results: the analysis of the frequency of these snps showed that the haplotype formed by foxp3 -3279 a allele occurred significantly more frequently in patients than controls (odds ratio=1.44, 95% ci=1.312-2.66; p=0.001). conclusion: our results suggest that polymorphism in foxp3 gene is associated with susceptibility to ar.
similar resources
FOXP3 and TGF-β Gene Polymorphisms in Allergic Rhinitis
Background: Regulatory CD4+T (Treg) cells are effective in maintaining immune tolerance. Objective: To investigate single nucleotide polymorphisms (SNPs) of Transforming Growth Factor β-1 (TGF-β1) and Forkhead Box Protein 3 (FOXP3) genes in Iranian patients with allergic rhinitis (AR). Methods: Variations at codons 10 and 25 of TGF-β1 and FOXP3 at positions -3279 A>C and -924 A>G were evaluated...
full textGATA3 Gene Polymorphisms Associated with Allergic Rhinitis in an Iranian Population
Background: The development of allergic rhinitis (AR) is caused by the interaction between genetic predisposition and environmental factors. In this study, the association between GATA3 single nucleotide polymorphisms and AR in an Iranian population was identified. Methods: This case-control study was performed on 86 patients with AR and 86 healthy subjects. This study aimed to e...
full textA significant increase in expression of FOXP3 and IL-17 genes in patients with allergic rhinitis underwent accelerated rush immunotherapy
Objective(s): Allergic rhinitis (AR) is a common hypersensitivity disease worldwide. Immunotherapy has been performed as the best treatment for years. This study aimed to study the gene expression pattern of immune system cells following an accelerated rush immunotherapy protocol (ARIT) in patients with AR.Materials and Methods: Fifteen ...
full textOral Administration of Zataria multiflora Extract Decreases IL-17 Expression in Perennial Allergic Rhinitis
Background: Rhinitis, which occurs most commonly as allergic rhinitis and affects 20% of the world’s population, is a major health care burden causing significant morbidity. Considering the high prevalence of allergic rhinitis and anti-inflammatory effects of thyme, a favorite condiment, we performed a randomized clinical trial to determine whether thyme can relieve allergic rhinitis symp...
full textassociation between tnfaip3 gene polymorphisms and risk of allergic rhinitis in a chinese han population
tumor necrosis factor alpha-inducible protein 3 (tnfaip3) gene polymorphisms have been reported to be associated with the susceptibility to several immune-related diseases. here we investigated the effect of tnfaip3 gene polymorphisms on the risk of allergic rhinitis (ar) in a chinese han population. the case-control study included 540 ar patients and 524 healthy controls. genotyping for tnfaip...
full textAssociation between polymorphisms in FOXP3 and EBI3 genes and the risk for development of allergic rhinitis in Chinese subjects.
OBJECTIVE To investigate whether polymorphisms in forkhead box protein 3 (FOXP3) and EBV-induced gene 3 (EBI3) genes are associated with allergic rhinitis (AR) in Chinese patients. METHODS A population-based case-control association study design was used to assess the risk of AR conferred by single nucleotide polymorphisms (SNPs) in FOXP3 and EBI3 gene regions. DNA was extracted from 378 pati...
full textMy Resources
Save resource for easier access later
Journal title:
iranian journal of immunologyجلد ۸، شماره ۴، صفحات ۲۱۸-۲۲۵
Keywords
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023